What Is Nadir?

When discussing chemotherapy side effects often you will hear the word nadir, mainly in reference to the blood counts, particularly White blood cell count and platelet count. Nadir basically means low point, however further explanation may clarify this term in connection with chemotherapy treatment.

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Nadir Affects Blood Cell & Platelet Counts

When chemotherapy is given it not only affects the rapidly dividing cancer cells but it also affects some of the normal cells of the body toàn thân. These effectsparticularly occur on normal cells that divide rapidly such as, the hair, the lining of the mouth, the cells lining the intestinal tract & the blood cells (trắng and red blood cells as well as platelets).

In the bone marrow, the spongy inner core of the larger bones in the body is where blood cells are made. There are very immature cells called stem cells, from which the various types of blood cells develop. These stem cells vị not reproduce quickly và are less likely to lớn be affected by chemotherapy. As cells are maturing there are certain phases in which they divide faster. It is during these times that the cells are most sensitive to chemotherapy. The more mature cells can continue khổng lồ become fully mature cells for several days after chemotherapy is given.

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When these cells live sầu out their life span, the circulating supply is depleted & the blood counts fall to lớn a low point, the nadir.

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Emerging from the Nadir và Returning to Normal

The blood counts will return lớn normal within three lớn four weeks, after the body"s feedbaông chồng system has told the stem cells in the bone marrow to increase production & begin making new cells. If chemotherapy is given at the time that the stem cells in the bone marrow are increasing their production this could cause permanent bone marrow damage. The timing of chemotherapy cycles takes this process into lớn account. For example some chemotherapy drugs are given on day 1 & day 8 of a 28-day cycle. The second dose of chemotherapy, one week after the first, is tolerated because the stem cells have not yet increased their production (they are still at the nadir). They have not increased their production because the second treatment is given before the count of the circulating blood has reached its nadir.

The nadir time is usually about 10 days after treatment, although this may vary depending on the drugs given. The concern during the nadir time is that the body"s first line of defense against infection, white blood cells (WBC) and the platelets, which help khổng lồ clot the blood, are low leaving a person more susceptible lớn infection & bleeding. The next dose of chemotherapy is given only after a person"s blood counts have sầu left the nadir và recovered to a safe level.

More Chemotherapy Information:

Chemotherapy Terms Chemotherapy Protocols - How Chemotherapy Works How Chemotherapy Is Given How Doctors Decide Which Chemotherapy Drugs To Give sầu How Long Chemotherapy Is Given How To Tell If Chemotherapy Is Working Cancer Cells & Chemotherapy Types of Chemotherapy Targeted Therapy The Immune System About Immunotherapy Hormone Therapy Chemoporotective sầu Agents Chemotherapy Resistance Short và Long Term Side Effects of Chemotherapy Nadir Cancer Clinical Trials is designed khổng lồ provide the latest information about chemotherapy to patients & their families, caregivers & friends. For information about the 4th Angel Mentoring Program visit